10-3561-100 10-3561
Monoclonal Antibody to Punctin-1 (clone: 1B2-8-2)
Abeomics
DESCRIPTION
Monoclonal antibody 1B2-8-2 reacts with Punctin-1 (ADAMTSL-1). Punctin-1 is a secreted molecule resembling members of the family of proteases designated ADAMTS (a disintegrin-like and metalloprotease domain with thrombospondin type I motif). ADAMTS proteases are secreted enzymes that consist of a metalloprotease domain (which provides the catalytic activity) and ancillary domains (which provide substrate, cell or extracellular matrix activity). Punctin-1 lacks the pro-metalloprotease and the disintegrin-like domain typical of this family but contains other ADAMTS domains in precise order including 4 thrombospondin-I repeats. Punctin-1 is an extracellular matrix protein in tissues and deposited into the cell substratum and localized towards the periphery of transfected cells. Punctin-1 and Punctin-2 (ADAMTSL-3) are the first members of a novel family of ADAMTS-like proteins that appear to have important functions in the extracellular matrix. Monoclonal antibody 1B2-8-2 recognizes the first thrombospondin repeat near the N-terminal and reacts with molecular species of 55 kDa or a doublet of 55 k Da and 60 kDa (glycosylated form). Note that proteolysis of Punctin-1 has been described and additional smaller bands may also be obtained.
DETAILS
- Gene: ADAMTSL1
- App Id: ELISA,WB
- Antigen: Punctin-1
- Gene Id: 92949
- Isotype: Mouse IgG2b
- Clone Name: 1B2-8-2
- Uniprot Id: Q8N6G6
- Host Animal: Mouse
- Clonality Id: Monoclonal
- Reactivity Id: Human
- Product Content: 0.2 µm filtered antibody solution in PBS containing 0.1% bovine serum albumin and 0.02% sodium azide.
- Alternative Name: ADAMTSR1, C9orf94
- Storage Condition: Product should be stored at 4°C. Under recommended storage conditions, product is stable for one year.
- Immunogen Information: thrombospondin repeat near the N-terminal
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