20-1044
Polyclonal antibody to Caspase-9
Abeomics
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DESCRIPTION
Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. A novel member in the caspase family was recently identified and designated ICE-LAP6, Mch6, and Apaf-3. Caspase-9 and Apaf-1 bind to each other, which leads to caspase-9 activation. Caspase-9 is also activated by granzyme B and CPP32. Activated caspase-9 cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. Caspase-9 play a central role in cell death induced by a wide variety of apoptosis activators including TNFalpha, TRAIL, anti-CD-95, FADD, and TRADD. Caspase-9 is expressed in a variety of human tissues. The Cleaved Caspase-9 polyclonal antibody preferntially recognizes (active) cleaved Caspase-9. Whereas the antibody has a strong preference for (active) cleaved Caspase-9, in some cell or tissue systems or techniques the antibody may also recognize the pro form of Caspase-9.
DETAILS
- Gene: CASP9
- App Id: WB,IHC,IP
- Antigen: Caspase-9
- Gene Id: 842
- Isotype: Rabbit IgG
- Format Id: Sera
- Uniprot Id: P55211
- Host Animal: Rabbit
- Clonality Id: Polyclonal
- Reactivity Id: Dog,Gerbil,Human,Mouse,Rat
- Product Content: 50 µl sera
- Alternative Name: CASP9||MCH6
- Application Note: WB: 1:1000-1:2000, IHC (paraffin): 1:1000-1:5000, IHC (frozen): Users should optimize, IP: 1:50-1:200
- Storage Condition: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
- Immunogen Information: A recombinant catalytically active of human Caspase-9 protein was used as the immunogen for this antibody