Calcitriol

DESCRIPTION

Calcitriol is the hormonally active metabolite of vitamin D with the addition of three hydroxyl groups. Its main biological effect is to increase the mineralization of bone and the uptake of calcium from the gut into the blood. Calcitriol activates osteoclasts by causing osteoblasts to release Receptor activator of nuclear factor kappa-B ligand (RANKL). It is also reported to exhibit antitumor properties by inhibiting the proliferation of a variety of carcinomas and leukemia cells.

DETAILS

Purity: ≥97%
Synonyms: Bocatriol, Calcijex, Decostriol, Osteotriol, Rocaltrol, Tirocal, D3, 1,25-Dihydroxyvitamin
Cas Number: 32222-06-3
References: Rigby, W. F., Stacy, T., & Fanger, M. W. (1984). Inhibition of T lymphocyte mitogenesis by 1, 25-dihydroxyvitamin D3 (calcitriol). Journal of Clinical Investigation, 74(4), 1451. Gross, C., Stamey, T., Hancock, S., & Feldman, D. (1998). Treatment of early recurrent prostate cancer with 1, 25-dihydroxyvitamin D3 (calcitriol). The Journal of urology, 159(6), 2035-2040. Daniel, C., Sartory, N. A., Zahn, N., Radeke, H. H., & Stein, J. M. (2008). Immune modulatory treatment of trinitrobenzene sulfonic acid colitis with calcitriol is associated with a change of a T helper (Th) 1/Th17 to a Th2 and regulatory T cell profile. Journal of Pharmacology and Experimental Therapeutics, 324(1), 23-33.
Application: FA
Formulation: Crystalline solid
Chemical Name: (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
Molecular Weight: 416.6
Molecular Formula: C27H44O3
Storage Conditions: Product should be kept at -20°C.
Pubchem Openeye Can Smiles: CC(CCCC(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C