6493124-25mg 6493124-10mg
Pifithrin-mu
Biogems
DETAILS
- Purity: ≥98%
- Synonyms: pifithrin-mu, 2-phenylacetylenesulfonamide, NSC 303580
- Cas Number: 64984-31-2
- References: Strom, E., Sathe, S., Komarov, P. G., Chernova, O. B., Pavlovska, I., Shyshynova, I., ... & Gudkov, A. V. (2006). Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation. Nature chemical biology, 2(9), 474-479. Leu, J. J., Pimkina, J., Pandey, P., Murphy, M. E., & George, D. L. (2011). HSP70 inhibition by the small-molecule 2-phenylethynesulfonamide impairs protein clearance pathways in tumor cells. Molecular Cancer Research, 9(7), 936-947. Sekihara, K., Harashima, N., Tamaki, Y., Hieda, Y., Uchida, N., Inomata, T., & Harada, M. (2013, September). Antitumor effect induced by combination of radiation with a novel HSP70 inhibitor pifithrin-mu on human prostate cancer. InEUROPEAN JOURNAL OF CANCER (Vol. 49, pp. S232-S233). THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND: ELSEVIER SCI LTD.
- Application: FA
- Formulation: Crystalline solid
- Chemical Name: 2-phenylethynesulfonamide
- Molecular Weight: 181.2
- Molecular Formula: C8H7NO2S
- Storage Conditions: Product should be kept at -20°C.
- Pubchem Openeye Can Smiles: C1=CC=C(C=C1)C#CS(=O)(=O)N
DESCRIPTION
Pifithrin-mu is a cell-permeable inhibitor of p53, which plays a crucial role in apoptosis, angiogenesis, and genomic stability. It is reported to be capable of increasing the efficiency of inducing pluripotent stem cells and reduce radiation induced cell death. Unlike the alpha version, Pifithrin-mu inhibits the p53-mitochornidral pathway without affecting the transcriptional functions of p53.