E2567Mo
Mouse Wap Four-Disulfide Core Domain Protein 2, WFDC2 ELISA Kit
Bioassay Technology Laboratory
DESCRIPTION
WAP four-disulfide core domain protein 2 - also known as Human Epididymis Protein 4 (HE4) - is a protein that in humans is encoded by the WFDC2 gene. HE4 is a tumor marker of ovarian cancer, with 80% sensitivity at a cut-off of 150 pmol/L. This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers.[5] The encoded protein is a small secretory protein, which may be involved in sperm maturation.
DETAILS
- GeneID: 67701
- Species: Mouse
- Storage: 2-8ºC
- MASS(Da): 18,032
- Synonyms: 1600023A02Rik;HE4;WA;WAP domain-containing protein HE4;WAP four-disulfide core domain protein 2;WAP5;WFDC2
- Assay Time: 1h 30m
- Assay Type: Sandwich
- Gene Names: Wfdc2
- Reactivity: Mouse
- Sample Type: Serum, plasma, cell culture supernates
- Sensitivity: 14.22ng/L
- Target Protein: WFDC2
- Detection Range: 30-9000ng/L
- Full Product Name: WAP four-disulfide core domain protein 2
- Standard Solution: 9600ng/L
- UniProt Accession: Q9DAU7