DUSP12 Antibody (N-term) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 11266
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: DUSP12
Other Names: Dual specificity protein phosphatase 12, Dual specificity tyrosine phosphatase YVH1, DUSP12
Availability: 2 weeks
Bio Background: DUSP12 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP12 is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain.
Bio References: Muda, M., et al., J. Biol. Chem. 274(34):23991-23995 (1999).Groom, L.A., et al., EMBO J. 15(14):3621-3632 (1996).
Primary Accession: Q9UNI6
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP8454a was selected from the N-term region of human DUSP12. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.