RP01805
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Recombinant Human TNFSF8/CD30 Ligand/CD153 Protein
ABclonal
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DESCRIPTION
CD30 ligand (CD30L), also known as CD153 and TNFSF8, is a membrane-associated glycoprotein belonging to the TNF superfamily and TNFR superfamily, and is a specific ligand for CD30/TNFRSF8 originally described as a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. CD30L is a type-II membrane glycoprotein expressed on activated T cells, stimulated monocyte-macrophages, granulocytes, eosinophils, and some Burkitt-like lymphoma cell lines. CD30L is capable of transducing signals through CD30 on different CD30+ lymphoma cell lines, and mediates pleiotropic biologic effects including cell proliferation, activation, differentiation, as well as cell death by apoptosis. CD30-CD30 ligand interaction has been suggested to have a pathophysiologic role in malignant lymphomas, particularly Hodgkin disease, large cell anaplastic lymphomas and Burkitt lymphomas, and is also involved in activation and functioning of the T cell-dependent immune response. Thus, CD153 and its receptor CD30 are regarded as therapeutic targets in hematologic malignancies, autoimmune and inflammatory diseases.
DETAILS
- Tag: N-His
- Source: HEK293 cells
- Gene Id: 944
- Species: Human
- Lead Time: 3 to 5 weekdays
- Swiss Prot: P32971
- Research Areas: Cytokines & Cytokine receptors
- Alternative Names: CD153; CD30L; CD30LG; TNLG3A;TNFSF8
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