30-1448
Anti-GRAP2/GADS Monoclonal Antibody (Clone:UW40)
Abeomics
DESCRIPTION
GRAP2/GADS (Grb2-related adaptor protein 2 / Grb2-related adaptor downstream of Shc) is a cytoplasmic adaptor protein containing N- and C-terminal SH3 domains flanking a central SH2 domain and a proline/glutamine-rich region. It is expressed predominantly in lymphoid tissue and hematopoietic cells, particularly in T cells. GRAP2/GADS plays a pivotal role during the early events of T cell signal transduction by recruiting the adaptor protein SLP-76 and its associated molecules, such as Vav, Nck, Itk, and ADAP, to the transmembrane adaptor protein LAT. GRAP2/GADS also binds several other signaling proteins, namely Gab2, HPK1 (hematopoietic progenitor kinase 1), and Cbl. Unlike similar adaptor protein Grb2, GRAP2/GADS shows higher selectivity when binding to the particular phosphorylated tyrosines of LAT adaptor.
DETAILS
- Gene: GRAP2
- App Id: FACS, IP, WB
- Antigen: GRAP2/GADS
- Gene Id: 9402
- Isotype: Mouse IgG2a
- Format Id: Purified
- Clone Name: UW40
- Uniprot Id: O75791
- Host Animal: Mouse
- Clonality Id: Monoclonal
- Purification: Purified by protein-A affinity chromatography
- Reactivity Id: Human
- Alternative Name: GRAP2||GADS||GRB2L||GRID
- Application Note: Flow Cytometry Recommended dilution:1 µg/ml Immunoprecipitation Western Blotting
- Storage Condition: Store at 2-8°C. Do not freeze.
- Immunogen Information: GST-fusion human GRAP2/GADS protein
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