EM574

DESCRIPTION

A motilin receptor agonist (IC50 = 6.17 nM for binding to rabbit gastric antral smooth muscle homogenates); binds to human smooth muscle homogenates (Kd = 7.8 nM); induces contraction of isolated rabbit intestine (EC50 = 5.5 nM); increases antral motility and enhances gastric emptying in canine models of gastroparesis at 0.03 mg/kg intraduodenally following a semi-solid meal

DETAILS

Inchi: InChI=1S/C39H69NO12/c1-15-27-39(12,45)32(42)22(6)30-20(4)17-38(11,52-30)34(51-36-29(41)26(16-21(5)47-36)40(13)19(2)3)23(7)31(24(8)35(44)49-27)50-28-18-37(10,46-14)33(43)25(9)48-28/h19,21-29,31-34,36,41-43,45H,15-18H2,1-14H3/t21-,22+,23+,24-,25+,26+,27-,28+,29-,31+,32-,33+,34-,36+,37-,38-,39-/m1/s1
Purity: ≥98%
Raptas: Product Type|Biochemicals|Receptor Pharmacology|Agonists
Smiles: CC[C@H]([C@](O)(C)[C@H](O)[C@@H](C)C1=C(C)C[C@](O1)(C)[C@]([H])(O[C@@]2([H])[C@H](O)[C@@H](N(C(C)C)C)C[C@@H](C)O2)[C@@H](C)[C@@](O[C@]3([H])O[C@@H](C)[C@H](O)[C@](C)(OC)C3)([H])[C@H]4C)OC4=O
Inchikey: FPBKIOZMKHHNLL-CBUZSSJJSA-N
Cas Number: 110480-13-2
Formulation: A solid
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C39H69NO12
Formula Weight: 744
Shelf Life Days: 1460