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sc-65262 SAMPLE sc-65262

Promo Available Scientist.com Supplier

CD39 (BU61)

Santa Cruz Biotechnology

DESCRIPTION

mouse monoclonal IgG1; CD39 Antibody (BU61) is an IgG1 κ mouse monoclonal CD39 antibody (also designated CD39 antibody) that detects the CD39 protein of human origin by WB, IP, IF and FCM. CD39 Antibody (BU61) is available as the non-conjugated anti-CD39 antibody. CD39, also known as ectonucleoside triphosphate diphosphohydrolase 1 (ENP1), is an integral membrane glycoprotein that acts as an extracellular nucleotide-hydrolyzing enzyme. CD39 inhibits ADP-induced platelet aggregation by hydrolyzing ADP to AMP and ultimately generating adenosine. Intracellular CD39 undergoes glycosylation at 6 N-glycosylation sites and translocates to the membrane in order to be an active enzyme. Alternative splicing gives rise to three CD39 isoforms, vascular, placenta I and placenta II. The placenta I isoform differs at the amino terminus whereas the placenta II isoform is missing amino acids 300-510 at the C-terminus. CD39 is expressed in vascular tissues including placenta, lung, skeletal muscle and kidney, as well as endothelium, smooth muscle, cardiac cells, lymphocytes (such as activated B cells) activated NK cells, macrophages, dendridic cells and platelets. CD39 may be used as an anti-thrombic agent for pre-treating patients at risk for coronary artery occlusion and thrombic stroke.

DETAILS

  • Host: mouse
  • Type: Primary
  • Uniprot: P49961
  • Clonality: Monoclonal
  • Conjugate: unconjugated
  • Applications: WB, IP, IF, FCM
  • Human Gene Id: 953
  • Protein Target: CD39
  • Human Gene Name: ENTPD1
  • Species Reactivity: human

PROMOTION TERMS

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.