Trabectedin

DESCRIPTION

An alkaloid with anticancer activity; a guanine-specific DNA alkylating agent; an antagonist of PXR (IC50 = ~3 nM); reduces viability of DU145 and PC3 human prostate cancer stem cells in a concentration-dependent manner; inhibits tumor growth in a PDOX mouse model of leiomyosarcoma at 0.15 mg/kg per week

DETAILS

Inchi: InChI=1S/C39H43N3O11S/c1-16-9-20-10-22-37(46)42-23-13-50-38(47)39(21-12-25(48-5)24(44)11-19(21)7-8-40-39)14-54-36(30(42)29(41(22)4)26(20)31(45)32(16)49-6)28-27(23)35-34(51-15-52-35)17(2)33(28)53-18(3)43/h9,11-12,22-23,29-30,36-37,40,44-46H,7-8,10,13-15H2,1-6H3/t22-,23-,29+,30+,36+,37-,39+/m0/s1
Purity: ≥95%
Raptas: Product Type|Biochemicals|DNA Alkylating Agents||Product Type|Biochemicals|Natural Products|Alkaloids||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|DNA Damage and Repair|DNA Alkylating Agents||Research Area|Toxicology & Xenobiotic Metabolism|Xenobiotic Sensing
Smiles: O[C@@H]([C@]1([H])CC2=CC(C)=C3OC)N([C@](COC4=O)([H])C5=C(OCO6)C6=C7C)[C@@]([C@@](N1C)([H])C2=C3O)([H])[C@@](SC[C@@]4(NCCC8=C9)C8=CC(OC)=C9O)([H])C5=C7OC(C)=O
Inchikey: PKVRCIRHQMSYJX-AIFWHQITSA-N
Cas Number: 114899-77-3
Formulation: A solid
Item Origin: Synthetic
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C39H43N3O11S
Formula Weight: 761.8
Shelf Life Days: 1460