Z03026-10
Scientist.com Supplier
PF-4/CXCL4, Human
GenScript
DESCRIPTION
Platelet factor 4, also known as CXCL4, is expressed in megakaryocytes and stored in the α-granules of platelets. Recombinant human PF-4 is a 7.8 kDa protein containing 70 amino acid residues, including the four highly conserved residues present in CXC chemokines. Platelet factor 4 can be antiproliferative and antiangiogenic, at least in part via interfering with FGF2 and VEGF heparin binding and thus inhibiting their signaling. However, it can also be proinflammatory and proatherogenic through multiple effects on monocytes, macrophages and endothelial cells.
DETAILS
- Form: Lyophilized
- Purity: > 95% as analyzed by SDS-PAGE> 95% as analyzed by HPLC
- Species: Human
- Product Line: Chemokines
- Expression System: HEK 293
- Storage Stability: Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.
- Biological Activity: ED50 < 10.0 ug/ml, measured by its ability to inhibit human FGF-basic-dependent proliferation of NR6R 3T3 mouse fibroblast cells.
- Protein Construction: CXCL4 (Glu32-Ser101)\nAccession # P02776