mouse monoclonal IgG1; Nopp140 Antibody (E-7) is an IgG1 κ mouse monoclonal Nopp140 antibody (also designated Nopp140 antibody) that detects the Nopp140 protein of mouse, rat and human origin by WB, IP, IF and ELISA. Nopp140 Antibody (E-7) is available as both the non-conjugated anti-Nopp140 antibody form, as well as multiple conjugated forms of anti-Nopp140 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Nopp140, previously named p130, is a nucleolar phosphoprotein that has been shown to exist in multiple forms with different sizes. Nopp140 functions both as a chaperone for import and/or export from the nucleolus and as a transcription factor. Nopp140 was originally identified from rat liver as an NLS (nuclear localization signal)-binding protein, and has been further characterized as an RNAP (RNA Polymerase)-interacting protein. Nopp140 also associates with the general transcription factor TFIIB, and the protein kinase casein kinase II (CKII). CKII heavily phosphorylates Nopp140 to mediate binding of Nopp140 to NLS. Nopp 140 colocalizes with another nucleolar protein, NAP57, in the nucleolus and coiled bodies, and is thought to be involved in activities carried out within the nucleolus.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.