BMS 270394

DESCRIPTION

A RARγ agonist (EC50 = 30 nM in a transactivation assay) and the active enantiomer of BMS 189961; selective for RARγ over RARβ (EC50 = 400 nM) and is inactive at RARα; synergizes with paclitaxel to inhibit the growth of MCF-7 breast and OVCAR-3 ovarian cancer, as well as SqCC/Y1 head and neck squamous cell carcinoma, cells

DETAILS

Inchi: InChI=1S/C23H26FNO4/c1-22(2)9-10-23(3,4)16-11-13(5-7-15(16)22)19(26)20(27)25-18-8-6-14(21(28)29)12-17(18)24/h5-8,11-12,19,26H,9-10H2,1-4H3,(H,25,27)(H,28,29)/t19-/m1/s1
Purity: ≥98%
Raptas: Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cancer||Research Area|Endocrinology & Metabolism|Hormones & Receptors|RARs, RORs, & RXRs
Smiles: OC(C1=CC(F)=C(NC([C@H](O)C2=CC(C(C)(C)CCC3(C)C)=C3C=C2)=O)C=C1)=O
Inchikey: AANFHDFOMFRLLR-LJQANCHMSA-N
Cas Number: 262433-54-5
Formulation: A solid
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C23H26FNO4
Formula Weight: 399.5
Shelf Life Days: 1460