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PI-050

Scientist.com Supplier

N-Ethylmaleimide

Isca Biochemicals

DESCRIPTION

N-Ethylmaleimide is a sulfhydryl alkylating reagent which has been used for blocking sulfhydryl containing reagents which interfere with glucose oxidase assays. N-Ethylmaleimide inactivates NADP-dependent isocitrate dehydrogenase and is also an endonuclease inhibitor. N-Ethylmaleimide is also a potent inhibitor of both Mg2+ and Ca2+/Mg2+-stimulated DNA fragmentation in rat liver nuclei.

DETAILS

  • Mf: C6H7NO2
  • Mw: 125.13
  • Refs: Huang et al (1995) N-ethylmaleimide profiling of yeast NADP-dependent isocitrate dehydrogenase. Arch. Biochem. Biophys. 316(1) 485 PMID: 7840654Lain et al (1994) Dependence of the folding and import of the precursor to mitochondrial aspartate aminotransferase on the nature of the cell-free translation system. J. Biol. Chem. 269(22) 15588 PMID: 8195205Zhao and Brunger (2016) Recent Advances in Deciphering the Structure and Molecular Mechanism of the AAA+ ATPase N-Ethylmaleimide-Sensitive Factor (NSF). J. Mol. Biol. 428 (9 Part B) 1912 PMID: 26546278Related areasAll small molecules >All dehydrogenase modulators >
  • Cas No: 128-53-0
  • Purity: ‰¥98% by HPLC
  • Target: Dehydrogenases,Endonucleases
  • Storage: Store desiccated, frozen and in the dark
  • Sequence: 1-Ethyl-1H-pyrrole-2,5-dione
  • Appearance: White solid
  • Solubility: Soluble in ethananol
  • Producttype: Small molecules
  • Threelettersequence: 1-Ethyl-1H-pyrrole-2,5-dione