Human CCR9 Protein, His,Avitag™&Flag Tag (Detergent)

DESCRIPTION

The protein encoded by this gene is a G protein-coupled receptor with seven transmembrane domains that belongs to the beta chemokine receptor family. Chemokines and their receptors are key regulators of thymocyte migration and maturation in normal and inflammation conditions. This gene is differentially expressed in T lymphocytes of the small intestine and colon, and its interaction with chemokine 25 contributes to intestinal intra-epithelial lymphocyte homing to the small intestine. This suggests a role for this gene in directing immune responses to different segments of the gastrointestinal tract. This gene and its exclusive ligand, chemokine 25, are overexpressed in a variety of malignant tumors and are closely associated with tumor proliferation, apoptosis, invasion, migration and drug resistance. This gene maps to the chemokine receptor gene cluster. Multiple transcript variants encoding different isoforms have been found for this gene.

DETAILS

Tag: N-Flag & C-10×His & C-Avi
Host: HEK293
Size: 500ug
Buffer: 50 mM HEPES, 150 mM NaCl, DDM, CHS, pH7.5
Format: Liquid
Source: Human CCR9 Protein, His,Avitag&Flag Tag (CC9-H82D3) is expressed from human 293 cells (HEK293). It contains AA Thr 2 - Ala 244 & Lys 245 - Leu 369 (Accession # P51686-1).
Storage: -70℃
Category: MABSol® Biotin Labeled Proteins
Molecule: CCR9
Conjugate: Biotin-labeled
Stability: ● The product MUST be stored at -70°C or lower upon receipt; ● -70°C for 3 months under sterile conditions.
Exp Region: Thr 2 - Ala 244 & Lys 245 - Leu 369
Swiss-prot: P51686-1
Package Size: 500ug*1
Characteristics: This protein carries a Flag tag at the N-terminus and a polyhistidine tag at the C-terminus followed by an Avi tag (Avitag™). The protein has a calculated MW of 47.7 kDa. The protein migrates as 50 kDa and 65-180 kda when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 47.7 kDa
Shipping Condition: Dry ice
Species Reactivity: Human
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