Vesnarinone

DESCRIPTION

A PDE3 inhibitor and ERG1 channel blocker (IC50s = 10.7, 13.2, and 1.1 μM for PDE3A, PDE3B, and ERG1, respectively); increases contractile tension in isolated ventricular muscles of dog, cat, rabbit, and guinea pig in a dose-dependent manner; increases right ventricular pressure with no effect on heart rate in dog models of tricuspid insufficiency- and pulmonary stenosis-induced congestive heart failure; increases contractility and coronary flow while decreasing heart rate in a guinea pig model of aortic stenosis-induced congestive heart failure

DETAILS

Inchi: InChI=1S/C22H25N3O4/c1-28-19-7-3-16(14-20(19)29-2)22(27)25-11-9-24(10-12-25)17-5-6-18-15(13-17)4-8-21(26)23-18/h3,5-7,13-14H,4,8-12H2,1-2H3,(H,23,26)
Purity: ≥98%
Raptas: Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Small Molecule Inhibitors|Phosphodiesterases||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Cardiovascular System|Cardiovascular Diseases|Heart Failure||Research Area|Cardiovascular System|Heart|Arrhythmia||Research Area|Cardiovascular System|Heart|Myocardial Contractility||Research Area|Cardiovascular System|Vasculature||Research Area|Cell Biology|Cell Signaling|cAMP Signaling||Research Area|Cell Biology|Cell Signaling|cGMP Signaling
Smiles: COC1=CC=C(C(N2CCN(C3=CC(CCC(N4)=O)=C4C=C3)CC2)=O)C=C1OC
Inchikey: ZVNYJIZDIRKMBF-UHFFFAOYSA-N
Cas Number: 81840-15-5
Formulation: A crystalline solid
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C22H25N3O4
Formula Weight: 395.5
Shelf Life Days: 1460