MU1-C5252-100ug MU1-C5252-1mg
Cynomolgus Mucin-1 / MUC-1 Protein, Fc Tag
ACROBiosystems
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DESCRIPTION
Membrane mucins have several functions in epithelial cells including cytoprotection, extravasation during metastases, maintenance of luminal structure, and signal transduction. MUC17, contains an extended, repetitive extracellular glycosylation domain and a carboxyl terminus with two EGF-like domains, a SEA module domain, a transmembrane domain, and a cytoplasmic domain with potential serine and tyrosine phosphorylation sites. Interacts via its C-terminus with PDZK1 and this interaction appears important for proper localization. Probably plays a role in maintaining homeostasis on mucosal surfaces.
DETAILS
- Tag: C-Fc
- Host: HEK293
- Size: 1mg
- Buffer: 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
- Format: Powder
- Purity: 90%
- Source: Cynomolgus Mucin-1, Fc Tag (MU1-C5252) is expressed from human 293 cells (HEK293). It contains AA Leu 254 - Gly 373 (Accession # XP_005541632.1).
- Storage: -20℃
- Category: Bio-Markers & CD Antigens
- Molecule: Mucin-1
- Accession: XP_005541632.1
- Conjugate: Unconjugated
- Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
- Exp Region: Leu 254 - Gly 373
- Package Size: 500ug*2
- Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The mature Mucin-1 is a non-covalent heterodimeric complex with the proteolytically cleaved N-terminal fragment and C-terminal fragment. Each N-terminal fragment and C-terminal fragment has a calculated MW of 7.2 kDa and 32.8 kDa. The protein migrates as 48 kDa (precursor protein) and 40-45 kDa (C-terminus) under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Endotoxin Level: 1.0 EU per μg
- Molecular Weight: 7.2 kDa and 32.8 kDa
- Shipping Condition: RT
- Species Reactivity: Cynomolgus
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