30-2812
Anti-Hu CD271 Purified
Abeomics
Image
DESCRIPTION
CD271 / NGFR, also known as p75NGFR or p75NTR, is a 75 kDa low affinity receptor for the NGF (nerve growth factor), BDNF (brain-derived growth factor), and other neurotrophins, such as NT3 and NT4/5. Unlike other members of the tumor necrosis factor receptor superfamily of transmembrane proteins, CD271 has unique intracellular domain structure (lacks catalytic activity) and downstream signaling partners. Triggered by its ligands CD271 affects growth, differentiation, migration and death of the nervous system cells.Specificity :The mouse monoclonal antibody NGFR5 (originally C34C) recognizes an epitope within ammino acids 1 - 160 of CD271/NGFR, a 75 kDa transmembrane glycoprotein of the TNFR superfamily.
DETAILS
- Gene: NGFR
- App Id: FACS, IP, WB, IHC, ICC, MC
- Antigen: CD271
- Gene Id: 4804
- Format Id: Purified
- Clone Name: NGFR5
- Uniprot Id: P08138
- Clonality Id: Monoclonal
- Purification: Purified by protein-A affinity chromatography.
- Reactivity Id: Human, Rabbit, Cat, Non-human primates, Ferret
- Product Content: Concentration: 1 mg/mlStorage Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- Alternative Name: nerve growth factor receptor TNFRSF16, NGFR, p75NTR, p75NGFR
- Application Note: Immunohistochemistry (paraffin sections): Recommended dilution: 1-2 µg/ml; Positive tissue: melanoma, heat-mediated antigen retrieval. Flow cytometry: Extracellular and intracellular staining; recommended dilution: 1-4 µg/ml.
- Storage Condition: Store at 2-8°C. Do not freeze.
- Immunogen Information: Purified CD271 protein isolated from human melanoma cell line A875