E4717Hu
Human Raftlin, RFTN1 ELISA Kit
Bioassay Technology Laboratory
DESCRIPTION
Involved in protein trafficking via association with clathrin and AP2 complex (PubMed: 27022195, PubMed: 21266579). Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed: 27022195, PubMed: 21266579). Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (By similarity). May regulate B-cell antigen receptor-mediated signaling (PubMed: 12805216). May play a pivotal role in the formation and/or maintenance of lipid rafts (PubMed: 12805216).
DETAILS
- Gene Id: 23180
- Uniprot: Q14699
- Lead Time: 3 days
- Assay Type: Sandwich
- Sample Type: Serum, plasma, cell culture supernates
- Sensitivity: 0.41ng/ml
- Detection Range: 0.5-40ng/ml
- Detection Method: ELISA
- Species Reactivity: Human