Human Annexin A5 Protein, His Tag

DESCRIPTION

Annexin A5 is a phospholipid binding protein, which binds with high affinity and selectivity to PS in the presence of calcium. PS is predominantly located in membrane leaflets, which face the cytosol. However, recent findings show that each cell type has the molecular machinery to expose PS at its cell surface. This machinery is activated during the execution of apoptosis. Once PS is exposed at the cell surface it exhibits procoagulant and proinflammatory activities. Annexin A5 will bind to the PS-exposing apoptotic cell and can inhibit the procoagulant and proinflammatory activities of the dying cell. Annexin A5 has also been identified as an anticoagulant protein in the blood coagulation cascade, by acting as an inhibitor of prothrombin activation. The presence of antibodies to Annexin A5 is associated with systemic lupus erythematosus (SLE), recurrent spontaneous abortions and systemic sclerosis (SSc).

DETAILS

Tag: C-6×His
Host: E. coli
Size: 100ug
Buffer: PBS, pH7.4
Format: Powder
Purity: 98%
Source: Human Annexin A5, His Tag (AN5-H5123) is expressed from E. coli cells. It contains AA Met 1 - Asp 320 (Accession # P08758-1).
Storage: -20℃
Category: Other Recombinant Proteins
Molecule: Annexin A5
Accession: AAH01429
Conjugate: Unconjugated
Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Exp Region: Met 1 - Asp 320
Swiss-prot: P08758-1
Package Size: 100ug*1
Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 36.8 kDa. The protein migrates as 35 kDa under reducing (R) condition (SDS-PAGE).
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 36.8 kDa
Shipping Condition: RT
Species Reactivity: Human
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