Human TIM-4 / TIMD4 Protein, His Tag

DESCRIPTION

The T cell immunoglobulin mucin (TIM) proteins regulate T cell activation and tolerance. An essential step during clearance of apoptotic cells is the recognition of phosphatidylserine (PS) exposed on apoptotic cells by its receptors on phagocytes. The phosphatidylserine (PS) receptor Tim-4 mediates phagocytosis of apoptotic cells by binding to PS exposed on the surface of these cells, and thus functions as a PS receptor for apoptotic cells. Tim-4 directly binding to PS and functioning as a tethering receptor for phagocytosis of apoptotic cells has been extensively studied over the past decade. However, the molecular mechanisms by which Tim-4 collaborates with other engulfment receptors during efferocytosis remain elusive.

DETAILS

Tag: C-10×His
Host: HEK293
Size: 100ug
Buffer: PBS, pH7.4
Format: Powder
Purity: 95%
Source: Human TIM-4 Protein, His Tag (TI4-H52H3) is expressed from human 293 cells (HEK293). It contains AA Glu 25 - Gln 314 (Accession # Q96H15-1).
Storage: -20℃
Category: Immune Checkpoint Proteins
Molecule: TIM-4
Conjugate: Unconjugated
Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Exp Region: Glu 25 - Gln 314
Swiss-prot: Q96H15-1
Package Size: 100ug*1
Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 33.4 kDa. The protein migrates as 55-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 33.4 kDa
Shipping Condition: RT
Species Reactivity: Human
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