mouse monoclonal IgG2b; p22-phox Antibody (E-11) is an IgG2b κ mouse monoclonal p22-phox antibody (also designated CYBA antibody, cytochrome b-245 alpha chain antibody, orp22PHOX antibody) that detects the p22-phox protein of mouse, rat and human origin by WB, IP, IF and ELISA. p22-phox Antibody (E-11) is available as both the non-conjugated anti-p22-phox antibody form, as well as multiple conjugated forms of anti-p22-phox antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Mox1 and the glycoprotein gp91-phox are largely related proteins that are essential components of the NADPH oxidase. The superoxide-generating NADPH oxidase is present in phagocytes, neuroepithelial bodies, vascular smooth muscle cells and endothelial cells. It includes a membrane-bound flavocytochrome containing two subunits, gp91-phox and p22-phox, and the cytosolic proteins p47-phox and p67-phox. During activation of the NADPH oxidase, p47-phox and p67-phox migrate to the plasma membrane, where they associate with the flavocytochrome cytochrome b558 to form the active enzyme complex. The p22- and gp91-phox subunits also function as surface O2 sensors that initiate cellular signaling in response to hypoxic conditions.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.