mouse monoclonal IgG1; Superoxide Dismutase 2/SOD2 Antibody (18) is an IgG1 mouse monoclonal SOD-2 antibody (also designated SOD-2 antibody) that detects SOD-2 of human origin by WB, IP and ELISA. Superoxide Dismutase 2/SOD2 Antibody (18) is available as the non-conjugated anti-SOD-2 antibody form, as well as multiple conjugated forms of anti-SOD-2 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The superoxide dismutase family is composed of three metalloenzymes (SOD-1, SOD-2 and SOD-3) that catalyze the oxido-reduction of reactive oxygen species (ROS) such as superoxide anion. The SOD-2 precursor is a 222 amino acid protein that is encoded by nuclear chromatin, synthesized in the cytosol and imported posttranslationally into the mitochondrial matrix. Unlike SOD-1, which is a homodimeric cytosolic Cu-Zn enzyme, SOD-2 is a homotetrameric manganese enzyme (also known as MnSOD) that functions in the mitochondrion. ROS are implicated in a wide range of degenerative processes, including Alzheimer's disease, Parkinson's disease and ischemic heart disease. Homozygous mutant mice, which lack SOD-2, exhibit dilated cardiomyopathy, accumulation of lipid in liver and skeletal muscle, metabolic acidosis, oxidative DNA damage and respiratory chain deficiencies in heart and skeletal muscle. Polymorphisms in the SOD-2 gene have also been implicated in nonfamilial, idiopathic, dilated cardiomyopathy in humans.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.