RP00102
Recombinant Human GDNFR-alpha-1/GFRA1 Protein
ABclonal
DESCRIPTION
This protein is a member of the glial cell line-derived neurotrophic factor receptor (GDNFR) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature receptor. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. This receptor is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed.
DETAILS
- Tag: C-hFc&His
- Source: HEK293 cells
- Gene Id: 2674
- Species: Human
- Lead Time: 3-5 weekdays
- Swiss Prot: P56159
- Research Areas: Growth Factor
- Alternative Names: GFRA1,GDNFR,GDNFRA,GFR-ALPHA-1,RET1L,RETL1,TRNR1
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