Human IL-12B&IL-12A Heterodimer Protein, His Tag&Flag Tag

DESCRIPTION

Interleukin 12 (IL12) is also known as p70, and is an interleukin that is naturally produced by dendritic cells, macrophages and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation.IL12 is a heterodimeric cytokine, containing IL-12A (p35) and IL-12B (p40). IL-12 is involved in the differentiation of naive T cells into Th1 cells. It is known as a T cell-stimulating factor, which can stimulate the growth and function of T cells. It stimulates the production of IFN-γ and TNF-α from T cells and NK cells, and reduces IL-4 mediated suppression of IFN-γ. IL-12 plays an important role in the activities of natural killer cells and T lymphocytes. IL-12 also has anti-angiogenic activity, which means it can block the formation of new blood vessels.

DETAILS

Tag: C-10×His | C-Flag
Host: HEK293
Size: 20ug
Buffer: PBS, pH7.4
Format: Powder
Purity: 90%
Source: Human IL-12B&IL-12A Heterodimer Protein, His Tag&Flag Tag (IL2-H4210) is expressed from human 293 cells (HEK293). It contains AA Ile 23 - Ser 328 (IL-12B) & Arg 23 - Ser 219 (IL-12A) (Accession # P29460-1 (IL12B) & P29459-1 (IL12A)).
Storage: -20℃
Category: Cytokines&Growth Factors
Molecule: IL-12B & IL-12A
Accession: NP_002178.2 (IL12B) & NP_000873.2 (IL12A)
Conjugate: Unconjugated
Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Exp Region: Ile 23 - Ser 328 (IL-12B) & Arg 23 - Ser 219 (IL-12A)
Swiss-prot: P29460-1 (IL12B) & P29459-1 (IL12A)
Package Size: 20ug*1
Characteristics: Human IL-12B&IL-12A Heterodimer Protein, His Tag&Flag Tag is produced by co-expression of IL-12B and IL-12A, has a calculated MW of 36.6 kDa (IL-12B) and 23.8 kDa (IL-12A). Subunit IL-12B is fused with polyhistidine tag at the C-terminus and subunit IL-12A is fused with flag tag at the C-terminus. The reducing (R) heterodimer protein migrates as 45 kDa (IL12B) and 38-43 kDa (IL12A) respectively due to glyosylation.
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 36.6 kDa (IL12B) and 23.8 kDa (IL12A)
Shipping Condition: RT
Species Reactivity: Human
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