PAK6 Antibody Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 106821730;56924
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: PAK6
Other Names: Serine/threonine-protein kinase PAK 6, PAK-5, p21-activated kinase 6, PAK-6, PAK6, PAK5
Availability: 2 weeks
Bio Background: The PAK6 protein shares a high degree of sequence similarity with p21-activated kinase (PAK) family members. The proteins of this family are Rac/Cdc42-associated Ste20-like Ser/Thr protein kinases, characterized by a highly conserved amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. PAK kinases are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. PAK6 was found to interact with androgen receptor (AR), which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development. The p21-activated protein kinase 6 gene was found to be highly expressed in testis and prostate tissues and the encoded protein was shown to cotranslocate into the nucleus with AR in response to androgen.
Bio References: Ching, Y.P., et al., J. Biol. Chem. 278(36):33621-33624 (2003).Pandey, A., et al., Oncogene 21(24):3939-3948 (2002).Yang, F., et al., J. Biol. Chem. 276(18):15345-15353 (2001).
Other Accession: NP_064553
Primary Accession: Q9NQU5
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP7931a was selected from the region of human PAK6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.