mouse monoclonal IgG2b; SOCS-3 Antibody (6A463) is an IgG2b κ mouse monoclonal SOCS-3 antibody (also designated SOCS3 antibody, CIS3 antibody or STAT-induced STAT inhibitor 3 antibody) that detects the SOCS-3 protein of mouse, rat and human origin by WB, IP and ELISA. SOCS-3 Antibody (6A463) is available as the non-conjugated anti-SOCS-3 antibody. The SOCS (suppressor of cytokine signaling) gene family consists of a group of proteins that negatively regulate cytokine signal transduction. The SOCS family proteins contain a central SH2 domain and a carboxy-terminal region termed the "SOCS box." The SOCS-1 (also called SSI-1 and JAB), SOCS-2 (also called SSI-2 and CIS2) and SOCS-3 (also called SSI-3 and CIS3) genes are known to be upregulated by IL-6 and other cytokines. SOCS-4, SOCS-5, SOCS-6 and SOCS-7 were identified by their sequence homology with the SOCS box. CIS (for cytokine-inducible SH2-containing protein) is also a member of the SOCS family.