Canine FcRn / FCGRT&B2M Heterodimer Protein, His Tag&Tag Free (MALS & SPR verified)

DESCRIPTION

FCGRT & B2M heterodimer protein (FcRn complex) consist of two subunits: p51 (equivalent to FCGRT), and p14 (equivalent to beta-2-microglobulin), and forms an MHC class I-like heterodimer. Fc fragment of IgG, receptor, transporter, alpha (FCGRT) binds to the Fc region of monomeric immunoglobulins gamma and mediates the uptake of IgG from milk. FCGRT possible role in transfer of immunoglobulin G from mother to fetus. Beta-2-microglobulin (B2M) is a component of the class I major histocompatibility complex (MHC) and involved in the presentation of peptide antigens to the immune system.

DETAILS

Tag: C-10×His | Native
Host: HEK293
Size: 1mg
Buffer: PBS, pH7.4
Format: Powder
Purity: 95%
Source: Canine FCGRT&B2M Heterodimer Protein, His Tag&Tag Free (FCM-C52W8) is expressed from human 293 cells (HEK293). It contains AA Ala 23 - Pro 298 (FCGRT) & Val 28 - Asn 125 (B2M) (Accession # XP_038512242.1 (FCGRT) & NP_001271408.1 (B2M)).
Storage: -20℃
Category: MABSol® Fc Receptors
Molecule: FcRn (FCGRT & B2M)
Accession: XP_038512242.1 (FCGRT) & NP_001271408.1 (B2M)
Conjugate: Unconjugated
Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Exp Region: Ala 23 - Pro 298 (FCGRT) & Val 28 - Asn 125 (B2M)
Swiss-prot: XP_038512242.1 | NP_001271408.1
Package Size: 500ug*2
Characteristics: Canine FCGRT&B2M Heterodimer Protein, His Tag&Tag Free, produced by co-expression of FCGRT and B2M, has a calculated MW of 32.3 kDa (FCGRT) and 11.6 kDa (B2M). Subunit FCGRT is fused with a polyhistidine tag at the C-terminus and subunit Beta-2 microglobulin (B2M) contains no tag at the C-terminus. The reducing (R) protein migrates as 35-37 kDa (FCGRT) and 13 kDa (B2M) respectively due to glycosylation.
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 32.3 kDa (FCGRT) & 11.6 kDa (B2M)
Shipping Condition: RT
Species Reactivity: Canine
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