Monoclonal Antibody to CD11c (Clone: ABM4C58)

DESCRIPTION

CD11c/CD18 ( p150/95, or complement receptor 4, CR4) is a monocyte/macrophage-enriched integrin that has been reported to bind to a variety of ligands. These include cell surface proteins (LPS, ICAM-1, ICAM-2, ICAM-4 and VCAM-1), extracellular matrix proteins (collagen I), and soluble ligands (iC3b, heparin and fibrinogen). It is expressed in macrophages, monocytes, granulocytes, subsets of T and B cells, and dendritic cells. CD11c functions as a cell surface receptor for numerous soluble factors and proteins. The interaction mediates leukocyte interactions with other cell types and is a signal transducing receptor. It is found primarily on myeloid cells, where its expression is regulated both during differentiation and during monocyte maturation into tissue macrophages.

DETAILS

Gene: ITGAX
App Id: IHC,FACS
Antigen: CD11c
Gene Id: 3687
Isotype: Mouse IgG2b Kappa
Format Id: Purified
Clone Name: ABM4C58
Uniprot Id: P20702
Host Animal: Mouse
Clonality Id: Monoclonal
Purification: Protein G Chromatography
Reactivity Id: Human
Product Content: 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Alternative Name: ITGAX||CD11C
Application Note: Immunohistochemical analysis: 5-10 µg/ml FACS: 0.5 - 1 µg/10^6 cells
Storage Condition: Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Immunogen Information: A partial length recombinant CD11c protein (amino acids 620-835) was used as the immunogen for this antibody.