mouse monoclonal IgG1; ASGPR1 Antibody (A-5) is an IgG1 κ mouse monoclonal ASGPR1 antibody (also designated ASGR1 antibody, asialoglycoprotein receptor 1 antibody, or hetero-oligomeric asialoglycoprotein receptor major subunit 1 antibody) that detects the ASGPR1 protein of human origin by WB, IP, IF and ELISA. ASGPR1 Antibody (A-5) is available as both the non-conjugated anti-ASGPR1 antibody form, as well as multiple conjugated forms of anti-ASGPR1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The Asialoglycoprotein Receptor (ASGPR, also designated hepatic lectin) is a type II integral membrane protein and is expressed in hepatic cells. ASGPR is composed of two homologous subunits, ASGPR1 and ASGPR2, that form multimeric complexes. Both ASGPR1 and ASGPR2 contain four functional domains, which include a cytosolic domain, a transmembrane domain, a stalk domain and a carbohydrate recognition domain (CRD). The CRD allows ASGPR to bind glycoproteins with terminal galactose and N-acetylgalactosamine residues while in the presence of calcium. After binding, the ASGPR-glycoprotein complex is then internalized into the cell, where the receptor and ligand are dissociated and ASGPR returns to the cell membrane. ASGPR can also bind hepatitis B virus (HBV) and mediate the HBV-infection of liver cells. The specific interaction with HBV makes ASGPR a potential target for therapeutic purposes.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.