30-1783
APC Conjugated Anti-Notch 1 Monoclonal Antibody (Clone:mN1A)
Abeomics
DESCRIPTION
Notch 1 is a 270-300 kDa transmembrane heterodimeric protein with multiple extracellular growth factor-like repeats, and with an intracellular domain consisting of multiple different domain types. It serves as a receptor for membrane ligands, such as Delta 1, Jagged1 (CD339), and Jagged2, and regulates cell fate decisions. Upon ligand binding the transmembrane form of Notch 1 is repeatedly cleaved to provide approximately 120 kDa Notch intracellular fragment (NICD), which translocates to the nucleus and acts as a part of transcriptional complexes that alter differentiation, proliferation, and apoptosis. The highest level of Notch 1 expression is in brain, lung and thymus.
DETAILS
- Gene: Notch1
- App Id: FACS
- Antigen: Notch 1
- Gene Id: 18128
- Isotype: Mouse IgG1
- Clone Name: mN1A
- Uniprot Id: Q01705
- Host Animal: Mouse
- Clonality Id: Monoclonal
- Conjugate Id: APC
- Reactivity Id: Human
- Alternative Name: NOTCH1, TAN1, Motch A, mT14, p300
- Storage Condition: Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
- Immunogen Information: GST fusion protein containing cdc10-NCR region of mouse Notch1
Equivalent Items
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