Polyclonal Antibody to HDAC4/HDAC5/HDAC9 (Ab-246/259/220)

DESCRIPTION

Responsible for the deacetylation of ysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of arge multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Cress, W.D. and Seto, E. (2000) J Cell Physiol 184, 1-16. Vigushin, D.M. and Coombes, R.C. (2004) Curr. Cancer Drug Targets 4, 205-218. Marmorstein, R. (2001) Cell Mol ife Sci 58, 693-703. Thiagalingam, S. et al. (2003) Ann. N.Y. Acad. Sci. 983, 84-100.

DETAILS

Gene: HDAC4
App Id: WB,IHC,IF
Antigen: HDAC4/HDAC5/HDAC9 (Ab-246/259/220)
Gene Id: 9759
Isotype: Rabbit IgG
Format Id: Purified
Uniprot Id: P56524 /Q9UQL6 Q
Host Animal: Rabbit
Clonality Id: Polyclonal
Reactivity Id: Human,Mouse
Product Content: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Alternative Name: HD4/HD5/HD9
Application Note: Predicted MW: 140 124 111 kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
Storage Condition: Store the antibody at 4°C, stable for 6 months. For ong-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Immunogen Information: Peptide sequence around aa.244~248/257~261/218~222 (T-A-S-E-P) derived from Human HDAC4/HDAC5/HDAC9.