Human EphB4 Protein, His Tag

DESCRIPTION

Ephrin type-B receptor 4(EPHB4) is also known as HTK, MYK1 and TYRO11,is a member of Eph family. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by EPHB4 binds to Ephrin-B2 and plays an essential role in vascular development. EPHB4 and its ligand ephrin-B2 are specifically expressed on venous and arterial endothelial cells, respectively, and play an essential role in vascular development via bidirectional signals. The forward EPHB4 signaling inhibits cell adhesion, chemotaxis, angiogenesis and tumor growth. Incontrast, the reverse Ephrin-B2 signaling exerts the opposite effect. It has been reported that aberrant expression of EPHB4 is associated with prostate cancer and highly malignant breast cancers, accordingly, EPHB4 has potential application as a therapeutic candidate.

DETAILS

Tag: C-6×His
Host: HEK293
Size: 200ug
Buffer: PBS, pH7.4
Format: Powder
Purity: 97%
Source: Human EphB4, His Tag (EP4-H5229) is expressed from human 293 cells (HEK293). It contains AA Leu 16 - Ala 539 (Accession # NP_004435.3).
Storage: -20℃
Category: Bio-Markers & CD Antigens
Molecule: EphB4
Accession: NP_004435.3
Conjugate: Unconjugated
Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Exp Region: Leu 16 - Ala 539
Swiss-prot: P54760
Package Size: 200ug*1
Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 57.9 kDa. The protein migrates as 65-75 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 57.9 kDa
Shipping Condition: RT
Species Reactivity: Human
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