Human Siglec-10 Protein, Fc (L117A, L118A) Tag

DESCRIPTION

The siglecs (sialic acid-binding Ig-like lectins) are a distinct subset of the Ig superfamily with adhesion-molecule-like structure. We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs. Siglec-10 was identified through database mining of an asthmatic eosinophil EST library. The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products.

DETAILS

Tag: C-Fc(A2)
Host: HEK293
Size: 1mg
Buffer: PBS, pH7.4
Format: Powder
Purity: 95%
Source: Human Siglec-10 Protein, Fc (L117A, L118A) Tag (SI0-H5254) is expressed from human 293 cells (HEK293). It contains AA Met 17 - Thr 546 (Accession # Q96LC7-1).
Storage: -20℃
Category: Bio-Markers & CD Antigens
Molecule: Siglec-10
Accession: NP_149121.2
Conjugate: Unconjugated
Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Exp Region: Met 17 - Thr 546
Swiss-prot: Q96LC7-1
Package Size: 500ug*2
Characteristics: This protein carries a Fc (L117A, L118A) tag at the C-terminus. The protein has a calculated MW of 84.6 kDa. The protein migrates as 100-115 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. Mutations (L117A, L118A/EU number: L234A/L235A) in human immunoglobulin G1 (hIgG1) Fc diminish binding to FcγRI leading to a significant reduction in ADCC and CDC in comparison to wild type human IgG1.
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 84.6 kDa
Shipping Condition: RT
Species Reactivity: Human
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