RAD9 Antibody (S328) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 5883
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: RAD9A
Other Names: Cell cycle checkpoint control protein RAD9A, hRAD9, DNA repair exonuclease rad9 homolog A, RAD9A
Availability: 2 weeks
Bio Background: Rad9 is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein is found to possess 3' to 5' exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade.
Bio References: Maniwa, Y., et al., Cancer 103(1):126-132 (2005). Wang, W., et al., Proc. Natl. Acad. Sci. U.S.A. 101(48):16762-16767 (2004). Lindsey-Boltz, L.A., et al., (er) Nucleic Acids Res. 32(15):4524-4530 (2004). Toueille, M., et al., (er) Nucleic Acids Res. 32(11):3316-3324 (2004). Loegering, D., et al., J. Biol. Chem. 279(18):18641-18647 (2004).
Primary Accession: Q99638
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP6357f was selected from the S328 region of human RAD9. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.