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HY-148825

NP10679

MedChem Express

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DETAILS

  • Purity: >98%
  • Smiles: O=C(N1)CCC2=C1C=CC(OC[C@H](O)CN(CC3)CCN3C4=CC=C(C(F)(F)F)C=C4)=C2
  • Category: Reference compound
  • Lead Time: 1-2 days
  • Cas Number: 2914889-88-4
  • Molecular Weight: 449.47
  • Molecular Formula: C23H26F3N3O3

DESCRIPTION

NP10679 is a selective, pH dependent GluN2B subunit-specific N-methyl-D-aspartate (NMDA) receptor inhibitor with high oral bioavailability and good brain penetration. NP10679 inhibits GluN2B with IC50s of 23 and 142 nM at pH 6.9 and 7.6, respectively. NP10679 is a histamine H1 antagonist and a hERG channel inhibitor with IC50s of 73 and 620 nM, respectively. NP10679 is a reversible inhibitor of human liver CYP enzymes[1].

Lead Time: 1-2 days

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