Anti-Gemin 2 Antibody

DESCRIPTION

The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.

DETAILS

Host: Rabbit
Type: Primary
Uniprot: SwissProt: O14893 Human;SwissProt: Q9CQQ4 Mouse
Clonality: Rabbit polyclonal Antibody
Conjugate: Non-conjugated
Alias Names: Component of gems 2 antibody Gem (nuclear organelle) associated protein 2 antibody Gem associated protein 2 antibody GEMI2_HUMAN antibody Gemin-2 antibody gemin2 antibody SIP 1 antibody SIP-1 antibody SIP1 antibody SIP1 delta antibody SIP1-delta antibody SMN interacting protein 1 antibody SMN interacting protein 1 delta antibody SMN-interacting protein 1 antibody Survival interacting protein 1 antibody Survival of motor neuron protein interacting protein 1 antibody Survival of motor neuron protein-interacting protein 1 antibody
Application: WB,IHC-P
Epitope Region: Synthetic peptide within human Gemin 2 aa 230-280.
Protein Target: Gem-associated protein 2 Gemin-2 Component of gems 2 Survival of motor neuron protein-interacting protein 1 SMN-interacting protein 1
Target Species: Human,Mouse
Species Reactivity: Human,Mouse