RP01371
Recombinant Human B7-H3/CD276 Protein
ABclonal
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DESCRIPTION
B7 homolog 3 (B7-H3), a member of the immunoglobulin superfamily, is also known CD276, which contains two Ig-like C2-type (immunoglobulin-like) domains and two Ig-like V-type (immunoglobulin-like) domains.B7-H3 may play an important role in muscle-immune interactions, providing further evidence of the active role of muscle cells in local immunoregulatory processes. B7-H3 is a novel protein structurally related to the B7 family of ligands by the presence of a single set of immunoglobulin-V-like and immunoglobulin-C-like (VC) domains. Previous studies have correlated its overexpression with poor prognosis and decreased tumor-infiltrating lymphocytes in various carcinomas including uterine endometrioid carcinomas, and mounting evidence supports an immuno-inhibitory role in ovarian cancer prognosis. Recently, B7-H3 expression has been reported in several human cancers indicating an additional function of B7-H3 as a regulator of antitumor immunity.
DETAILS
- Tag: C-hFc&His
- Source: HEK293 cells
- Gene Id: 80381
- Species: Human
- Lead Time: 3-5 weekdays
- Swiss Prot: Q5ZPR3-2
- Research Areas: Immune Checkpoint,Bio-Markers & CD Antigens,Biosimilar Drug Targets
- Alternative Names: CD276, 4Ig-B7-H3, B7-H3, B7H3, B7RP-2, CD276 antigen,4Ig-B7-H3,B7-H3,B7H3,B7RP-2