Human TrkB / NTRK2 Protein, Fc Tag

DESCRIPTION

Neurotrophic tyrosine kinase receptor type 2 (NTRK2) is also known as BDNF/NT-3 growth factors receptor, Tropomyosin-related kinase B (TRKB) and TrkB tyrosine kinase, which belongs to the protein kinase superfamily or Tyr protein kinase family. Insulin receptor subfamily. NTRK2 / TrkB contains two Ig-like C2-type (immunoglobulin-like) domains, two LRR (leucine-rich) repeats, one LRRCT domain, one LRRNT domain, one protein kinase domain. NTRK2 / Trk-B is expressed in the central and peripheral nervous system. The catalytic activity of NTRK2 is “ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate”. NTRK2 / TrkB involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity.

DETAILS

Tag: C-Fc
Host: HEK293
Size: 100ug
Buffer: 50 mM Tris, 100 mM Glycine, pH7.5
Format: Powder
Purity: 98%
Source: Human TrkB, Fc Tag (NT2-H5254) is expressed from human 293 cells (HEK293). It contains AA Cys 32 - His 430 (Accession # AAH31835).
Storage: -20℃
Category: Bio-Markers & CD Antigens
Molecule: TrkB
Accession: AAH31835
Conjugate: Unconjugated
Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Exp Region: Cys 32 - His 430
Swiss-prot: Q16620
Package Size: 100ug*1
Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 70.4 kDa. The protein migrates as 86-116 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 70.4 kDa
Shipping Condition: RT
Species Reactivity: Human
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