DESCRIPTION

• Target: GABA A Receptor
• Gene Id: 14394
• Isotype: IgG2A
• Conjugate: RPE
• Immunogen: Fusion protein amino acids 355-394 of human GABA-A-R-Alpha1
• References: 1. Bracamontes J.R. and Steinbach J.H. (2008) J Bio Chem. 283: 26128-26136. 2. Macdonald R.L., Olsen R.W. (1993) Annu Rev Neurosci. 17: 569-602.
• Swiss-prot: P14867
• Specificity: Detects ~55kDa. No cross-reactivity against GABA-A-R-Alpha 2 or –Alpha3.
• Applications: WB | IHC | ICC/IF | AM
• Clone Number: N95/35 (Formerly sold as S95-35)
• Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
• Host Species: Mouse
• Product Type: Monoclonal
• Purification: Protein G Purified
• Concentration: 1 mg/ml
• Research Areas: Neuroscience | Neurotransmitter Receptors | GABA Receptors | GABAA Receptors
• Storage Buffer: PBS, 50% glycerol, 0.1% azide *Storage buffer may change when conjugated
• Accession Number: NP_034380.1
• Alternative Names: ECA4 antibody, EJM antibody, EJM5 antibody, Gaba receptor alpha 1 polypeptide antibody, GABA(A) receptor antibody, GABA(A) receptor subunit alpha 1 antibody, GABA(A) receptor subunit alpha-1 antibody, GABA(A) receptor, alpha 1 antibody, GABRA 1 antibody, GABRA1 antibody, Gamma aminobutyric acid (GABA) A receptor alpha 1 antibody, Gamma aminobutyric acid A receptor alpha 1 antibody, Gamma aminobutyric acid receptor subunit alpha 1 antibody, Gamma-aminobutyric acid receptor subunit alpha-1 antibody, GBRA1_HUMAN antibody
• Antibody Dilution: WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
• Cite This Product: StressMarq Biosciences Cat# SMC-346D-RPE, RRID: AB_2700769
• Immunogen Species: Human
• Storage Temperature: Conjugated antibodies should be stored according to the product label
• Shipping Temperature: Blue Ice or 4ºC
• Cellular Localization: Cell Membrane | Cell Junction | Synapse | Postsynaptic Cell Membrane
• Scientific Background: The GABA-A receptor is a member of the superfamily of fast acting ligand-gated ion channels. The individual subunits of these receptors have similar sequences and structural features (1). GABA-A receptors are the major fast inhibitory neurotransmitter gated ion channels in the brain (2).
• Certificate of Analysis: 1 µg/ml of SMC-346 was sufficient for detection of alpha1 GABA receptor in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
• Species Reactivity Full Name: Human | Mouse | Rat