mouse monoclonal IgG2a; MAVS Antibody (E-3) is an IgG2a κ mouse monoclonal MAVS antibody (also designated IPS1 antibody, or VISA antibody) that detects the MAVS protein of human origin by WB, IP, IF, IHC(P) and ELISA. MAVS Antibody (E-3) is available as both the non-conjugated anti-MAVS antibody form, as well as multiple conjugated forms of anti-MAVS antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. MAVS (mitochondrial antiviral-signaling protein), also known as IPS1, KIAA1271, VISA or CARDIF, is a 540 amino acid protein that contains one CARD domain and several transmembrane domains, and localizes to the outer mitochondrial membrane. Expressed throughout the body with highest ex-pression in liver, heart, placenta, skeletal muscle and peripheral blood leuk-ocytes, MAVS functions downstream of proteins, such as RIG-I, that detect double-stranded (ds) viral replication and is required for proper immune re-sponse against ds viral infection. MAVS is thought to activate pathways that lead to the induction of antiviral cytokines and may protect the cells from viral-induced apoptosis. MAVS function can be inactivated via cleavage by a protease complex that degrades the CARD and transmembrane domains, thereby preventing MAVS from interacting with other proteins. Three isoforms of MAVS are expressed due to alternative splicing events.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.