Ebselen

DESCRIPTION

Glutathione peroxidase mimetic [1, 4]. Peroxynitrite scavenger [4]. Anti-inflammatory [1, 5-7] Antioxidant [2, 3, 5]. Protein kinase C (PKC), NADPH, lipoxygenase, COX, NOS, H+-ATPase and NADPH oxidase inhibitor [6-9]. Antifungal [9]. Review [10]. Potent IDO-1 inhibitor with Ki 94nM [11]. Inhibitor of HIV-1 capsid C-terminal domain dimerization. Shown to potentially inhibit the 33.8-kDa Main Protease (Mpro)/3C-like Protease of SARS-CoV-2, consequently inhibiting viral transcription and replication and possibly inhibiting spread of COVID-19

DETAILS

Cas: 60940-34-3
Purity: greater than or equal to 98% (HPLC)
Smiles: O=C1N([Se]C2=C1C=CC=C2)C1=CC=CC=C1
Formula: C13H9NOSe
Storage: Short Term Storage:+4C. Long Term Storage: -20C. Handling Advice: Protect from light. Use/Stability: Stable for at least 2 years after receipt when stored at -20C.
Identity: Determined by 1H-NMR.
Shipping: Room Temp
Inchi Key: DYEFUKCXAQOFHX-UHFFFAOYSA-N
Solubility: Soluble in DMSO (25mg/ml), DMF (25mg/ml) or water (2mg/ml).
Merck Index: 3.004166667
Physical State: Lyophilized
Additional Names: 2-Phenyl-1,2-benzisoselenazol-3-(2H)-one
Predicted Molecular Weight: 274.2