Polyclonal Antibody to Caveolin-1 (Phospho-Tyr14)

DESCRIPTION

The scaffolding protein encoded by Caveolin-1 is the main component of the caveolae plasma membranes found in most cell types. The protein inks integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are ocated next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (a and beta) are encoded by a single transcript from this gene.

DETAILS

Gene: CAV1
App Id: WB,IF
Antigen: Caveolin-1 (Phospho-Tyr14)
Gene Id: 857
Isotype: Rabbit IgG
Format Id: Purified
Uniprot Id: Q03135
Host Animal: Rabbit
Clonality Id: Polyclonal
Reactivity Id: Human,Mouse,Rat
Product Content: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Alternative Name: CAV|| CAV1
Application Note: Predicted MW: 24kd, Western blotting: 1:500~1:1000, Immunofluorescence: 1:100~1:200
Storage Condition: Store the antibody at 4°C, stable for 6 months. For ong-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Immunogen Information: Peptide sequence around phosphorylation site of tyrosine 14 (H-L-Y(p)-T-V) derived from Human CAVEOLIN-1.