VU0409551

DESCRIPTION

An mGluR5 PAM; induces calcium mobilization in HEK293 cells expressing human mGluR5 (EC50 = 260 nM); selective for mGluR5 over mGluR1-4 and mGluR6-8 at 10 μM; reverses amphetamine-induced hyperlocomotion in rats (ED50 = 23 mg/kg), indicating antipsychotic-like activity; increases levels of c-fos and expression of BDNF, Arc/Arg3.1, syntaxin 1A, and PSD-95 in the hippocampus in the BACHD mouse model of Huntington’s disease at 3 mg/kg; improves object location memory in the novel object location test and associative memory in the cued fear conditioning test in the BACHD mouse model at 3 mg/kg

DETAILS

Inchi: InChI=1S/C20H17FN2O3/c21-15-8-6-14(7-9-15)20(24)23-11-10-17-18(12-23)26-19(22-17)13-25-16-4-2-1-3-5-16/h1-9H,10-13H2
Purity: ≥98%
Raptas: Product Type|Biochemicals|Receptor Pharmacology|Allosteric Modulators||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory||Research Area|Neuroscience|Behavioral Neuroscience|Schizophrenia & Psychosis||Research Area|Neuroscience|Neurodegenerative Disorders|Huntington’s Disease
Smiles: O=C(C1=CC=C(F)C=C1)N2CCC3=C(OC(COC4=CC=CC=C4)=N3)C2
Inchikey: QUZLMKNNIUSREV-UHFFFAOYSA-N
Cas Number: 1363281-27-9
Formulation: A crystalline solid
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C20H17FN2O3
Formula Weight: 352.4
Shelf Life Days: 1460