4831086-10mg 4831086-1mg
Purmorphamine
Biogems
DESCRIPTION
Purmorphamine is an activator of the Smoothened protein in the hedgehog signaling pathway. It is reported to induce osteogenesis and influence the differentiation and growth of neurons.
DETAILS
- Purity: ≥98%
- Synonyms: UNII-PB12M2F8KY, Shh Signaling Antagonist VI
- Cas Number: 483367-10-8
- References: Wu, X., Walker, J., Zhang, J., Ding, S., & Schultz, P. G. (2004). Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway. Chemistry & biology, 11(9), 1229-1238. Beloti, M. M., Bellesini, L. S., & Rosa, A. L. (2005). Purmorphamine enhances osteogenic activity of human osteoblasts derived from bone marrow mesenchymal cells. Cell biology international, 29(7), 537-541. Oliveira, F. S., Bellesini, L. S., Defino, H. L. A., da Silva Herrero, C. F., Beloti, M. M., & Rosa, A. L. (2012). Hedgehog signaling and osteoblast gene expression are regulated by purmorphamine in human mesenchymal stem cells. Journal of cellular biochemistry, 113(1), 204-208.
- Application: FA
- Formulation: Crystalline solid
- Chemical Name: 9-cyclohexyl-N-(4-morpholin-4-ylphenyl)-2-naphthalen-1-yloxypurin-6-amine
- Molecular Weight: 520.6
- Molecular Formula: C31H32N6O2
- Storage Conditions: Product should be kept at -20°C.
- Pubchem Openeye Can Smiles: C1CCC(CC1)N2C=NC3=C(N=C(N=C32)OC4=CC=CC5=CC=CC=C54)NC6=CC=C(C=C6)N7CCOCC7