mouse monoclonal IgG1; LAT1 Antibody (D-10) is an IgG1 κ mouse monoclonal LAT1 antibody (also designated Solute Carrier Family 7 Member 5 antibody, Solute Carrier Family 7 (Amino Acid Transporter Light Chain L System) Member 5 antibody, Large Neutral Amino Acids Transporter Small Subunit 1 antibody, L-Type Amino Acid Transporter 1 antibody, CD98 Light Chain antibody, CD98 antibody, Solute Carrier Family 7 (Cationic Amino Acid Transporter Y+ System) Member 5 antibody, Sodium-Independent Neutral Amino Acid Transporter LAT1 antibody, Y+ System Cationic Amino Acid Transporter antibody, or CD98LC antibody) that detects the LAT1 protein of mouse, rat and human origin by WB, IP, IF and ELISA. LAT1 Antibody (D-10) is available as both the non-conjugated anti-LAT1 antibody form, as well as multiple conjugated forms of anti-LAT1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. L-type amino acid transporter 1 (LAT1) is a multipass-membrane protein responsible for sodium-independent, high-affinity transport of large neutral amino acids. LAT1 functions as a disulfide-linked heterodimer with the amino acid transport protein CD98. LAT1 is expressed predominantly in adult lung and liver but is also expressed in brain, thymus, retina, testis, placenta, bone marrow and fetal liver. In the retina, LAT1 localizes to the blood-retinal-barrier (BRB) and mediates L-leucine transport from the blood to the retina. The devastating effects on the brain caused by phenylketonuria are due to the increased levels of LAT1 on the blood-brain-barrier in response to high concentrations of phenylalanine in the blood. LAT1 accepts the amino-acid related anticancer agent melphalan and plays a significant role in cell proliferation, differentiation, and invasion in esophageal squamous cell carcinoma.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.