Monoclonal Antibody to TLR4 / CD284 (Clone: ABM19C4)

DESCRIPTION

TLR4 (Toll-like receptor-4) is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. It primarily mediates cellular signaling induced by Gram negative bacteria. TLR4 is highly specific for LPS and it is associated with CD14, a co-receptor for LPS. The downstream signaling pathway of TLR4 leads to the activation of NF-kappaB through myeloid differentiation protein (MyD88) and IL-1 receptor-associated kinase in various cell types. Keratinocytes express TLR4 at the mRNA and protein levels whereas TLR4 are also present in the normal human epidermis in vivo and their expression is regulated by microbial components. TLR4 is expressed on CD4+ T cells as well, the functional significance of which is unclear.

DETAILS

Gene: TLR4
App Id: IHC,FACS,IF
Antigen: TLR4
Gene Id: 7099
Isotype: Mouse IgG2b Kappa
Format Id: Purified
Clone Name: ABM19C4
Uniprot Id: O00206
Host Animal: Mouse
Clonality Id: Monoclonal
Purification: Protein G Chromatography
Reactivity Id: Human
Product Content: 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Alternative Name: TLR4
Application Note: Immunohistochemical analysis: 5 µg/ml; FACS analysis: 2-4 µg/10^6
Storage Condition: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Immunogen Information: A partial length recombinant TLR4 protein (amino acids 45-320) was used as the immunogen for this antibody.