mouse monoclonal IgG2a; POLR1E Antibody (C-11) is an IgG2a κ mouse monoclonal POLR1E antibody (also designated POLR1E antibody) that detects the POLR1E protein of mouse, rat and human origin by WB, IP, IF and ELISA. POLR1E Antibody (C-11) is available as both the non-conjugated anti-POLR1E antibody form, as well as multiple conjugated forms of anti-POLR1E antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. RNA polymerase I (Pol I) is a multi-subunit complex responsible for catalyzing the transcription of DNA into RNA, specifically via the synthesis of ribosomal RNA precursors. POLR1E (polymerase (RNA) I polypeptide E), also known as PAF53 or PRAF1, is a 481 amino acid protein that localizes to the nucleolus and belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family. Existing as a component of the Pol I complex, POLR1E functions as a DNA-dependent RNA polymerase that uses the four ribonucleoside triphosphates as substrates to catalyze the transcription of DNA into RNA. The gene encoding POL1E maps to human chromosome 9, which houses over 900 genes and comprises nearly 4% of the human genome. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, and Familial dysautonomia, are both associated with chromosome 9. Notably, chromosome 9 encompasses the largest interferon family gene cluster.