RP01666
Recombinant Mouse B7-DC/PD-L2/CD273 Protein
ABclonal
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DESCRIPTION
Programmed Death Ligand 2 (PD-L2), also known as B7-DC and butyrophilin-like protein, is a member of the B7 family of proteins that provide signals for regulating T-cell activation and tolerance .PD-L2 is expressed on dendritic cells, subsets of activated CD4+ and CD8+ T cells, and memory B cells that differentiate into plasma cells. At inflammatory sites such as rheumatoid arthritis, allergen exposure, and virus infection, PD-L2 is up-regulated on synoviocytes, infiltrating macrophages, dendritic cells, and airway epithelial cells. PD-L2, along with B7-H1/PD-L1, binds to T cell PD-1 where it promotes IFN-gamma production and CD40 Ligand up-regulation while inhibiting IL-4 production. In addition, PD-L2 binds to RGM-B on macrophages and alveolar epithelial cells, supporting respiratory immune tolerance. In asthma, PD-L2 suppresses IL-5 and IL-13 production, promotes IL-12 production by dendritic cells, and supports allergen-induced airway hyper-responsiveness and mucus production.
DETAILS
- Tag: C-6His
- Source: HEK293 cells
- Gene Id: 58205
- Species: Mouse
- Lead Time: 3-5 weekdays
- Swiss Prot: Q9WUL5
- Research Areas: Immune Checkpoint,Bio-Markers & CD Antigens
- Alternative Names: Btdc; B7-DC; PD-L2; F730015O22Rik;PDCD1LG2;CD273
Equivalent Items
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